ABMIUM target intelligence
AKT1 substrate 1
AKT1S1 (AKT1 substrate 1; PRAS40) encodes proline-rich AKT1 substrate 1, a phosphorylation-sensitive regulator of mechanistic target of rapamycin complex 1 (mTORC1).
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Research context & evidence
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PRAS40/AKT1S1 negatively regulates mTORC1 by associating with the complex and limiting substrate access under low insulin or nutrient conditions. Insulin- and nutrient-responsive phosphorylation promotes 14-3-3 binding and relief of mTORC1 inhibition.
AKT1S1/PRAS40 is studied at the intersection of AKT signalling, nutrient sensing, mTORC1 control, cell growth and metabolic regulation. Catalogue-backed reagents should be selected using product-specific species and application validation.
Names used across publications, databases and supplier catalogues.
