RENFunctional association
UniProt and IntAct report interaction with renin, which proteolytically processes angiotensinogen in the renin-angiotensin system.
ABMIUM target intelligence
angiotensinogen
Angiotensinogen (AGT), also known as serpin A8/SERPINA8, is the precursor protein of angiotensin peptides in the renin-angiotensin system. This ABMIUM record connects NCBI Gene 183 and UniProtKB P01019 to catalogue-backed research products.
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Research context & evidence
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Angiotensinogen (AGT) is an essential precursor in the renin-angiotensin system. Renin cleavage generates angiotensin I, which is further processed to bioactive angiotensin peptides including angiotensin II, supporting regulation of blood pressure, vascular tone, body-fluid balance and electrolyte homeostasis.
Angiotensinogen/AGT is studied in the renin-angiotensin system, cardiovascular biology, blood-pressure regulation, renal physiology and fluid/electrolyte homeostasis. Review the linked ABMIUM research products and confirm species, sample type, application, assay format and product-level validation before use.
Names used across publications, databases and supplier catalogues.
These relationships provide research context only. They do not establish product or application suitability.
UniProt and IntAct report interaction with renin, which proteolytically processes angiotensinogen in the renin-angiotensin system.
UniProt reports angiotensin II derived from AGT as a ligand for AGTR1.
UniProt reports angiotensin II derived from AGT as a ligand for AGTR2.
Interpretation: Identity, aliases and biological context were checked against NCBI Gene 183 and reviewed UniProtKB P01019 on 2026-08-17. Catalogue association does not establish suitability for a specific experiment; confirm product-level validation and sample compatibility.