ABMIUM target intelligence
ADAM metallopeptidase with thrombospondin type 1 motif 4
ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4/ADAMTS-4), also known as aggrecanase-1, is an extracellular matrix metalloprotease strongly associated with proteoglycan turnover.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
ADAMTS4, also known as aggrecanase-1, is a secreted ADAMTS-family metalloprotease. Curated NCBI and reviewed UniProt annotations describe cleavage of aggrecan and cartilage oligomeric matrix protein (COMP); NCBI also reports brevican degradation.
ADAMTS4 is studied in extracellular-matrix remodelling, aggrecan turnover, cartilage degradation and arthritis-related biology. Reagent selection should be based on species, sample type, assay format, application and product-level validation.
Names used across publications, databases and supplier catalogues.
