ABMIUM target intelligence
amine oxidase copper containing 3
AOC3 (amine oxidase copper containing 3), widely known as vascular adhesion protein 1 (VAP-1) and semicarbazide-sensitive amine oxidase (SSAO), is a cell-surface copper amine oxidase studied in amine metabolism and leukocyte trafficking.
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Research context & evidence
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AOC3 is a copper-dependent primary amine oxidase that catalyses oxidative deamination of primary amines to aldehydes, producing hydrogen peroxide and ammonia. As vascular adhesion protein 1 (VAP-1), the endothelial cell-surface protein also has adhesion activity that contributes to lymphocyte extravasation and recirculation.
AOC3/VAP-1/SSAO is studied where enzymatic amine oxidation intersects with endothelial adhesion and inflammatory-cell trafficking. Because catalytic activity and adhesion are distinct experimental readouts, researchers should match reagent format, species and application to the question being tested.
Names used across publications, databases and supplier catalogues.
