ABMIUM target intelligence
allograft inflammatory factor 1
AIF1 is allograft inflammatory factor 1, widely recognised in research as IBA1 (ionized calcium-binding adapter molecule 1). It is a calcium- and actin-binding protein associated with myeloid-cell cytoskeletal responses and is commonly studied in macrophage and microglial biology.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
AIF1/IBA1 binds actin and calcium and contributes to cytoskeletal remodelling, membrane ruffling and cell motility. Reviewed evidence supports roles in RAC-dependent actin dynamics, phagocytic activity and macrophage activation, making AIF1 useful for investigating changes in myeloid-cell state and morphology.
AIF1/IBA1 is widely used in macrophage and microglial research, including inflammation, tissue injury and neuroimmune models. Because AIF1 abundance can vary with cellular state and experimental context, its measurement should be interpreted alongside morphology and complementary lineage or activation markers. Reagent selection should reflect species, sample type, assay format and product-level validation.
Names used across publications, databases and supplier catalogues.
