ABMIUM target intelligence
aconitase 1
Aconitase 1 (ACO1), also known as cytoplasmic aconitate hydratase and iron regulatory protein 1 (IRP1), is a bifunctional human protein linking citrate metabolism with iron-responsive post-transcriptional regulation.
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Research context & evidence
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ACO1 is a bifunctional cytosolic protein. When assembled with a [4Fe-4S] cluster it acts as aconitase, catalysing the reversible interconversion of citrate and isocitrate through cis-aconitate. Under iron-limiting conditions, loss of the cluster enables ACO1/IRP1 to bind iron-responsive elements in target mRNAs and regulate proteins involved in cellular iron uptake, storage and use.
ACO1/IRP1 is studied in iron homeostasis, iron-responsive element (IRE) regulation, cytosolic aconitase activity, oxidative stress and metabolic adaptation. Use the catalogue filters below to review ABMIUM products associated with aconitase 1 and confirm species, sample type, assay format, application and product-level validation before selecting a reagent.
Names used across publications, databases and supplier catalogues.
