ABMIUM target intelligence
BMP binding endothelial regulator
BMPER (BMP binding endothelial regulator), also called BMP-binding endothelial regulator protein or CV-2, is a secreted extracellular modulator of bone morphogenetic protein signalling.
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Research context & evidence
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BMPER is a secreted BMP-binding protein that regulates cellular responsiveness to bone morphogenetic proteins. Curated human evidence supports inhibitory effects on BMP signalling, including BMP2- and BMP4-dependent osteoblast and chondrogenic differentiation.
BMPER/CV-2 is studied in extracellular control of BMP signalling, osteoblast and chondrocyte differentiation, and vascular-development biology. Its activity is context dependent, so mechanistic conclusions should be tied to the experimental system and ligand environment.
Names used across publications, databases and supplier catalogues.
