ABMIUM target intelligence
apolipoprotein B
APOB (apolipoprotein B) encodes the major structural apolipoprotein of chylomicrons and low-density lipoproteins. Human APOB gives rise to two principal plasma forms: ApoB-100, synthesized mainly in the liver and acting as a ligand for the LDL receptor, and ApoB-48, produced in the intestine through RNA editing. Researchers use APOB to investigate lipoprotein particle biology, lipid transport and receptor-mediated clearance.
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Research context & evidence
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Apolipoprotein B provides the core protein scaffold for major circulating lipoprotein particles. ApoB-100 is the full-length hepatic form found in LDL and functions as a recognition ligand for LDL-receptor-mediated particle uptake. ApoB-48 is the shorter intestinal form in chylomicrons and is generated from the same APOB transcript by RNA editing that introduces an early stop codon. These forms link APOB to transport of triglyceride- and cholesterol-rich particles between tissues.
APOB is a central research target for studies of hepatic and intestinal lipoprotein production, LDL particle biology, cholesterol transport and LDL-receptor-dependent clearance. Distinguishing ApoB-48 from ApoB-100 is important when interpreting tissue, species, sample type and assay format because the two proteins arise from the same gene but differ in length, site of synthesis and lipoprotein context.
Names used across publications, databases and supplier catalogues.
