ABMIUM target intelligence
apelin
APLN (apelin; APEL) encodes the peptide-hormone precursor for active apelin peptides, endogenous ligands of the apelin receptor APLNR/APJ. Apelin signalling contributes to cardiovascular and fluid-homeostasis pathways and other tissue-specific physiological responses.
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Research context & evidence
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The APLN precursor is proteolytically processed into biologically active apelin peptides including apelin-36, apelin-31, apelin-28 and apelin-13. These peptides activate APLNR/APJ, engaging inhibitory G-protein and beta-arrestin signalling, reducing cAMP and activating ERK pathways.
APLN/apelin is studied as the endogenous ligand arm of the apelin-APLNR (APJ) signalling axis in cardiovascular homeostasis, vascular biology, fluid balance and metabolic signalling. ABMIUM catalogue links indicate research products associated with APLN; product-level application and species validation should be checked individually.
Names used across publications, databases and supplier catalogues.
