ABMIUM target intelligence
apolipoprotein L1
Apolipoprotein L1 (APOL1; ApoL-I/APO-L) is a secreted HDL-associated protein involved in lipid-transport biology and a pore-forming component of human serum trypanosome lytic factor. It is studied in lipoprotein transport and innate trypanolytic immunity.
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Research context & evidence
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Reviewed UniProt describes APOL1 as a possible participant in lipid exchange, lipid transport and reverse cholesterol transport, and as a crucial component of human trypanosome lytic factor. APOL1 forms pores in Trypanosoma brucei lysosomal membranes, contributing to parasite lysis; plasma APOL1 associates with ApoA-I-containing HDL particles.
APOL1 research spans HDL-associated lipid transport and innate trypanolytic immunity, including studies of pore formation and APOL1 sequence variation. Variant-specific conclusions require genotype- and context-specific evidence and should not be inferred from total APOL1 measurements alone.
Names used across publications, databases and supplier catalogues.
