IL6RFunctional association
IL6 binds IL6R as the first step in formation of the signalling receptor complex.
ABMIUM target intelligence
interleukin 6
IL6 encodes interleukin 6, a pleiotropic cytokine involved in immune signalling and acute-phase biology. This target hub connects verified human identifiers and aliases with ABMIUM antibodies, ELISA kits, proteins and related assay products.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
IL6 is a pleiotropic cytokine involved in immunity, tissue regeneration and metabolism. It binds IL6R and recruits the signalling subunit IL6ST/gp130 to activate IL6 pathways. IL6 can signal through membrane-bound IL6R (classic signalling) or soluble IL6R (trans-signalling), and it is a potent inducer of the acute-phase response.
IL6 is widely studied in inflammation, host defence, tissue injury, acute-phase biology and immune signalling. Excessive or dysregulated IL6 production is associated with disease pathology. Reagent selection should be based on species, sample type, assay format, application and product-level validation.
Names used across publications, databases and supplier catalogues.
These relationships provide research context only. They do not establish product or application suitability.
IL6 binds IL6R as the first step in formation of the signalling receptor complex.
The IL6-IL6R complex associates with IL6ST/gp130 to initiate intracellular IL6 signalling.
UniProt reports direct interaction with SORL1, which can promote IL6 internalization and lysosomal degradation and may modulate IL6 signalling.
Interpretation: Biological function and interaction context are based on the linked NCBI Gene and reviewed UniProtKB records. Catalogue association does not by itself establish experimental suitability for a specific application.