ABMIUM target intelligence
bone gamma-carboxyglutamate protein
BGLAP encodes bone gamma-carboxyglutamate protein, better known as osteocalcin (OC/BGP), a vitamin K-dependent osteoblast-secreted protein of mineralized bone matrix.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
Osteocalcin undergoes vitamin K-dependent gamma-carboxylation, enabling binding to calcium and hydroxyapatite. The carboxylated protein is a major non-collagenous component of bone matrix and contributes to bone formation and remodelling biology.
BGLAP/osteocalcin is widely studied in osteoblast differentiation, bone-matrix deposition, mineralization and bone-remodelling research. Its processing and carboxylation state can influence biochemical behaviour, so assay design and reagent validation should be matched to the experimental question.
Names used across publications, databases and supplier catalogues.
