ABMIUM target intelligence
alkaline phosphatase, biomineralization associated
ALPL (alkaline phosphatase, biomineralization associated) encodes tissue-nonspecific alkaline phosphatase (TNAP/TNSALP), a membrane-bound ectophosphatase central to extracellular phosphate metabolism and skeletal mineralization.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
The ALPL protein is the tissue-nonspecific alkaline phosphatase isozyme. It hydrolyses phosphate-containing substrates, including inorganic pyrophosphate (PPi) and pyridoxal 5'-phosphate. By reducing extracellular PPi, a mineralization inhibitor, ALPL supports hydroxyapatite formation and normal bone and tooth mineralization.
ALPL is studied in osteoblast differentiation, biomineralization, phosphate metabolism and alkaline-phosphatase activity assays. TNAP/TNSALP terminology is also widely used in research on tissue-nonspecific alkaline-phosphatase biology. Reagent selection should be matched to species, sample type, assay format, application and product-level validation.
Names used across publications, databases and supplier catalogues.
