ABMIUM target intelligence
aldo-keto reductase family 1 member B
AKR1B1 encodes aldo-keto reductase family 1 member B; its reviewed human protein is aldo-keto reductase family 1 member B1, widely known as aldose reductase (AR/ALR2).
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
AKR1B1 is an NADPH-dependent oxidoreductase that reduces diverse carbonyl-containing compounds. It catalyses glucose reduction to sorbitol, the first step of the polyol pathway, and also reduces endogenous, lipid-derived and xenobiotic carbonyls.
AKR1B1/aldose reductase research spans polyol-pathway metabolism, cellular carbonyl detoxification, redox biology and metabolic-stress models. Human nomenclature is kept distinct from mouse-family aliases stored for catalogue continuity.
Names used across publications, databases and supplier catalogues.
