ABMIUM target intelligence
argonaute RISC component 1
AGO1 (argonaute RISC component 1; protein argonaute-1) is an Argonaute-family RNA-binding protein that uses small regulatory RNAs to guide gene silencing. It is studied as a core component of miRNA- and siRNA-associated post-transcriptional regulation.
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Research context & evidence
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Protein argonaute-1 binds microRNAs (miRNAs) and small interfering RNAs (siRNAs) and uses their sequence information to recognize complementary RNA targets. AGO1 supports RNA interference and RNA silencing, including translational repression and degradation of miRNA-bound mRNA targets; NCBI also describes a role in transcriptional gene silencing of complementary promoter regions.
AGO1 is useful in research on RNA interference, miRNA and siRNA effector complexes, post-transcriptional gene regulation and small-RNA pathway organization. Experimental interpretation should distinguish AGO1 abundance or localization from the sequence-specific activity of the small RNAs loaded into Argonaute complexes.
Names used across publications, databases and supplier catalogues.
