Primärantikörper geliefert von Boster Bio
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Die metabolische N-Oxidation des aus der Nahrung stammenden Amino-Trimethylamins (TMA) wird durch Flavin-haltige Monooxygenasen vermittelt und unterliegt einem vererbten FMO3-Polymorphismus beim Menschen, der zu einer kleinen Subpopulation mit reduzierter TMA-N-Oxidationskapazität führt, die das Fischgeruchssyndrom Trimethylaminurie hervorruft. Drei Formen des Enzyms, FMO1, das in der fetalen Leber gefunden wird, FMO2, das in der erwachsenen Leber gefunden wird, und FMO3, werden durch Gene kodiert, die in der Region 1q23-q25 gruppiert sind. Flavin-haltige Monooxygenasen sind NADPH-abhängige Flavoenzyme, die die Oxidation von weichen nukleophilen Heteroatomzentren in Medikamenten, Pestiziden und Xenobiotika katalysieren. Für dieses Gen wurden mehrere Transkriptvarianten gefunden, die verschiedene Isoformen kodieren.
Fully tested in-house by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human | ||||||||
| Mouse | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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