MEK4 (F194)Rabbit pAb from ELK Biotechnology Read more ›
MEK4 (F194)Rabbit pAb is a research-use antibody from ELK Biotechnology for studying MEK4 (F194)Rabbit pAb in WB workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.
SAPK/Erk kinase (SEK1), also known as MEK4 or MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines . Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop . Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction .
| Validation evidence captions | Western blot analysis of 1) A431 Cell Lysate, 2) Mouse Brain Tissue Lysate , 3) Rat Brain Tissue Lysate using MEK4（EA362）Rabbit pAb diluted at 1:2000. |
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| Collaborator | ELK Biotechnology |
| Partner model | EA362 |
| Target | MEK4 (F194)Rabbit pAb |
| Research areas | Antibody Research |
| Reactivity | Human,Mouse,Rat |
| Applications | WB |
| Conjugation | Unconjugated |
| Dilution range | WB 1:1,000-2,000 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant Protein |
| Concentration | 1mg/mL |
| Assay type | Antibody validation/application |
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse | |||||||
| Rat |
| Species | Dilution | Notes |
|---|---|---|
| Human | WB 1:1 | — |
| Mouse | — | — |
| Rat | — | — |
Collaborator meets ABMIUM quality standards and overall product performance standards have been met.
Quality management certification.
For research applications. Not for diagnostic use.
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