UniProt reports direct regulatory interaction with MDM2 leading to TP53 ubiquitination and proteasomal degradation.
ABMIUM target intelligence
tumor protein p53
TP53 identifies tumor protein p53 in Homo sapiens (Human). This target record connects NCBI Gene 7157, UniProtKB P04637 and related ABMIUM catalogue products.
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Names used across publications, databases and supplier catalogues.
TP53 encodes p53, a multifunctional DNA-binding transcription factor that responds to cellular stress by regulating programmes including cell-cycle arrest, DNA repair and apoptosis. Its activity is controlled by extensive protein interactions and post-translational regulation.
TP53 / p53 is studied in DNA-damage responses, cell-cycle control, apoptosis and cancer biology. Use the catalogue filters below to compare ABMIUM reagents by species, application and validation, and confirm product-level suitability before use.
Interaction context
Explore biologically relevant proteins connected to TP53 through receptor complexes, pathway context, curated molecular relationships or database-supported functional evidence. Each relationship should be interpreted independently and does not establish reagent suitability.
UniProt reports direct regulatory interaction with MDM2 leading to TP53 ubiquitination and proteasomal degradation.
UniProt reports TP53 interaction with the histone acetyltransferase EP300 in transcriptional regulation.
UniProt reports interaction with HIPK2 in TP53 regulatory complexes.
Interpretation: Identity and identifiers were checked against NCBI and reviewed UniProtKB. Biological function and listed interactions are conservatively paraphrased from UniProt evidence. Catalogue association does not establish suitability for a specific assay.