ABMIUM target intelligence
aldehyde dehydrogenase 2 family member
ALDH2 (aldehyde dehydrogenase 2 family member), also known as mitochondrial aldehyde dehydrogenase, is a mitochondrial matrix enzyme that oxidises acetaldehyde and other aldehydes. Researchers use ALDH2 to study aldehyde metabolism, alcohol metabolism and mitochondrial responses to carbonyl stress.
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ALDH2 is the mitochondrial aldehyde dehydrogenase isoform with low affinity constant for acetaldehyde and is localised to the mitochondrial matrix. It catalyses a major step in oxidative alcohol metabolism by converting acetaldehyde to acetate.
ALDH2 research commonly examines ethanol-derived acetaldehyde handling, mitochondrial aldehyde metabolism, genotype-dependent enzyme activity and cellular responses to acetaldehyde exposure. Experimental interpretation should distinguish ALDH2 abundance from catalytic function.