{"product_id":"elk-es1065-cleaved-integrin-alphav-hc-k889-rabbit-pab","title":"Cleaved-Integrin αV HC (K889) rabbit pAb","description":"\u003cp\u003eCleaved-Integrin αV HC (K889) rabbit pAb is a research-use antibody from ELK Biotechnology for studying Integrin αV in WB, ELISA workflows with listed reactivity for Human, Rat, Mouse. Specifications and supporting documents below should be reviewed when planning the experiment.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eintegrin subunit alpha V(ITGAV) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eCleaved-Integrin αV HC (K889) Polyclonal Antibody detects endogenous levels of fragment of activated Integrin αV HC protein resulting from cleavage adjacent to K889.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using Cleaved-Integrin αV HC (K889) Polyclonal Antibody | Western blot analysis of lysates from A549 cells, treated with etoposide 25uM 1h, using ITGAV (heavy chain,Cleaved-Lys889) Antibody. The lane on the right is blocked with the synthesized peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56184947802452,"sku":"ABM102838","price":220.0,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56184947835220,"sku":"ABM92974","price":132.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1065-c-1.jpg?v=1782028245","url":"https:\/\/www.abmium.com\/zh\/products\/elk-es1065-cleaved-integrin-alphav-hc-k889-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}