{"product_id":"human-il-1-beta-elisa-kit-ez-set-diy-antibody-pairs-ez0392","title":"Human IL-1 beta ELISA Kit EZ-Set™ (DIY Antibody Pairs)","description":"\u003cp\u003eHuman IL-1 beta ELISA Kit EZ-Set™ (DIY Antibody Pairs) is a research-use antibody from Boster Bio for studying Interleukin-1 beta in ELISA workflows with listed reactivity for Human. Specifications and supporting documents below should be reviewed when planning the experiment.\u003c\/p\u003e\nHuman \u003ca href=\"https:\/\/www.bosterbio.com\/human-il-1-beta-picokine-trade-elisa-kit-ek0392-boster.html\" style=\"color:#EA8D28\"\u003eIL-1 beta ELISA Kit\u003c\/a\u003e EZ-Set™ (DIY Antibody Pairs) (\u003ca href=\"https:\/\/www.bosterbio.com\/services\/custom-rabbit-monoclonal-antibody-development-service\/antibody-pairs-development-service\" style=\"color:#EA8D28\"\u003eantibody pairs\u003c\/a\u003e and standards for assay development). Quantitate Human IL1B in cell culture supernatants, serum and plasma (heparin, EDTA, citrate).\u003cp\u003eInterleukin-1beta (IL-1beta) is a potent stimulator of bone resorption whose gene is mapped to 2q14, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1beta, a prominent microglia-derived cytokine, caused oligodendrocyte death in coculture with astrocytes and microglia, but not in pure culture of oligodendrocytes alone. It also can cause nuclear export of a specific NCOR corepressor complex, resulting in derepression of a specific subset of nuclear factor-kappa-B (NFKB)-regulated genes. Furthermore, Microenvironmental IL-1beta and, to a lesser extent, IL-1alpha are required for in vivo angiogenesis and invasiveness of different tumor cells. Additional, the cooperation of IL-1beta and PDGFB induces contractile-to-synthetic phenotype modulation of human aortic smooth muscle cells in culture. Moreover, the association with disease may be explained by the biologic properties of IL-1beta, which is an important proinflammatory cytokine and a powerful inhibitor of gastric acid secretion.\u003c\/p\u003e\u003ch3\u003eProduct information\u003c\/h3\u003e","brand":"Boster Bio","offers":[{"title":"5 plates\/kit","offer_id":56042539647316,"sku":"ABM31906","price":443.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ez0392_2.png?v=1781658811","url":"https:\/\/www.abmium.com\/sv\/products\/human-il-1-beta-elisa-kit-ez-set-diy-antibody-pairs-ez0392","provider":"ABMIUM","version":"1.0","type":"link"}