{"product_id":"elk-es1323-hdac4-phospho-ser632-rabbit-pab","title":"HDAC4 (phospho Ser632) rabbit pAb","description":"\u003cp\u003eHDAC4 (phospho Ser632) rabbit pAb is a research-use antibody from ELK Biotechnology for studying HDAC4 in WB, ELISA workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation\/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase\/acuc\/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-HDAC4 (S632) Polyclonal Antibody detects endogenous levels of HDAC4 protein only when phosphorylated at S632.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using Phospho-HDAC4 (S632) Polyclonal Antibody diluted at 1:1000 | Western blot analysis of HELA SH-SY5Y 3T3 lysis using Phospho-HDAC4 (S632) antibody. Antibody was diluted at 1:1000 | Western blot analysis of lysates from 293 cells treated with etoposide 25uM 1hour and Jurkat cells treated with etoposide 25uM 24hours, using HDAC4 (Phospho-Ser632) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56185309954388,"sku":"ABM104451","price":220.0,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56185309987156,"sku":"ABM94587","price":132.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1323-c-1.jpg?v=1782034325","url":"https:\/\/www.abmium.com\/sv\/products\/elk-es1323-hdac4-phospho-ser632-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}