{"product_id":"tribio-zm-447439-aurora-b-kinase-inhibitor","title":"ZM-447439, Aurora B kinase inhibitor","description":"\u003cp\u003eZM-447439 is a selective ATP-competitive inhibitor of Aurora kinase B1 (IC50 = 50 nM, Aur A IC50 = 1 µM, Aur C IC50 = 250 nM at physiological ATP concentrations, Ref.1 lists Aur A IC50 = 110nM and Aur B IC50 = 113nM). It did not significantly inhibit a panel of 14 other kinases including mitotic kinases CDK1 and PLK1. It prevents chromosome alignment, spindle checkpoint function and cytokinesis\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411090973012,"sku":"ABM148982-1","price":258.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411091005780,"sku":"ABM148982-2","price":78.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1037.png?v=1791105184","url":"https:\/\/www.abmium.com\/products\/tribio-zm-447439-aurora-b-kinase-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}