{"product_id":"tribio-vismodegib-hedgehog-signaling-pathway-inhibitor","title":"Vismodegib, Hedgehog signaling pathway inhibitor","description":"\u003cp\u003eA potent and selective Hedgehog (Hh) pathway signaling inhibitor antagonizing SMO with a Ki of 1.3 nM). Alters intracellular Ca2+ homeostasis and inhibits growth of cisplatin-resistant lung cancer cells. Inhibits two ABC transporters, ABCG2\/BCRP and ABCB1\/Pgp, IC50s=1.4 and 3.0 μM respectively. Clinically useful for the treatment of basal cell carcinoma. Inhibits proliferation and induces apoptosis in colon cancer cell lines\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411075014996,"sku":"ABM148941-1","price":327.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411075047764,"sku":"ABM148941-2","price":98.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2182.png?v=1791105147","url":"https:\/\/www.abmium.com\/products\/tribio-vismodegib-hedgehog-signaling-pathway-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}