{"product_id":"tribio-unc-2170-hcl-methyl-lysine-binding-protein-inhibitor","title":"UNC-2170 HCl, Methyl-lysine binding protein inhibitor","description":"\u003cp\u003eUNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411080716628,"sku":"ABM148909-1","price":589.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411080749396,"sku":"ABM148909-2","price":147.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1558.png?v=1791105161","url":"https:\/\/www.abmium.com\/products\/tribio-unc-2170-hcl-methyl-lysine-binding-protein-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}