{"product_id":"tribio-tolcapone-comt-inhibitor-ttr-aggregation-inhibitor","title":"Tolcapone, COMT inhibitor; TTR aggregation inhibitor","description":"\u003cp\u003eCatechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes. Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity. Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo. Inhibits O-methylation of exogenous polyphenols such as EGCG. Cell permeable. Orally bioavailable\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"10 MG","offer_id":57411081306452,"sku":"ABM148864-1","price":82.0,"currency_code":"GBP","in_stock":true},{"title":"50 MG","offer_id":57411081339220,"sku":"ABM148864-2","price":327.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI3075.png?v=1791105162","url":"https:\/\/www.abmium.com\/products\/tribio-tolcapone-comt-inhibitor-ttr-aggregation-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}