{"product_id":"tribio-th588-mth1-nudt1-inhibitor","title":"TH588, MTH1\/NUDT1 inhibitor","description":"\u003cp\u003eTH588 is a first-in-class nudix hydrolase family inhibitor. MTH1\/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death. TH588 inhibits MTH1\/NUDT1 (IC50 = 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells. Active in vitro and in vivo. Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411089924436,"sku":"ABM148843-1","price":270.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411089957204,"sku":"ABM148843-2","price":90.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4602.png?v=1791105181","url":"https:\/\/www.abmium.com\/products\/tribio-th588-mth1-nudt1-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}