{"product_id":"tribio-sr0987-ror-t-agonist","title":"SR0987, RORγt agonist","description":"\u003cp\u003eRORγt is a T cell specific isoform of ROR that is a key transcription factor for initiating the differentiation of Th17 and Tc17 cells. SR0987 (303126-97-8) is a RORγt agonist that drives proliferation of Th17 cells and decrease levels of the immune checkpoint protein PD-1. In a Ga14 UAS-Luc cotransfection system, SR0987 induced reporter gene expression (EC50 = 800nM). Treatment of human Jurkat T cells with SR0987 resulted in decreased cell surface PD-1 expression. RORγt agonists may synergize with current anti-PD-1 therapy and represent a new potential class of cancer immunotherapeutic\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411084091732,"sku":"ABM148773-1","price":425.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411084124500,"sku":"ABM148773-2","price":114.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4008.png?v=1791105168","url":"https:\/\/www.abmium.com\/products\/tribio-sr0987-ror-t-agonist","provider":"ABMIUM","version":"1.0","type":"link"}