{"product_id":"tribio-sb-225002-cxcr2-antagonist","title":"SB-225002, CXCR2 antagonist","description":"\u003cp\u003ePotent and selective CXCR2 receptor antagonist (IC50 = 22 nM). Displays \u0026gt;150-fold selectivity over CXCR1 receptors. Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and by inducing mitotic catastrophe. Blocks IL-8-mediated cellular effects such as oxidative stress-induced cellular senescence and neutrophil chemotaxis1. Inhibits HIV replication in lymphocytes and macrophages. Inhibits endothelial activation and leukocyte recruitment to cerebral microvessels during neuroinflammation\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411056206164,"sku":"ABM148707-1","price":392.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411056238932,"sku":"ABM148707-2","price":98.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2850.png?v=1791104969","url":"https:\/\/www.abmium.com\/products\/tribio-sb-225002-cxcr2-antagonist","provider":"ABMIUM","version":"1.0","type":"link"}