{"product_id":"tribio-salubrinal-eif2-phosphatase-inhibitor-er-stress-inhibitor","title":"Salubrinal, eIF2α Phosphatase inhibitor; ER stress inhibitor","description":"\u003cp\u003eEndoplasmic reticulum (ER) stress inhibitor. Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2α). It has been found to interact with the anti-apoptotic protein Bcl-2 offering protection from the apoptotic and autophagic effects that result from loss of Bcl-2 function. Salubrinal blocked NFATc1 expression and osteoclast differentiation by RANKL via phosphorylation of eLF2α resulting in a decrease of global protein synthesis. It efficiently blocked osteoporosis in a mouse model treated with RANKL\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411053912404,"sku":"ABM148701-1","price":311.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411053945172,"sku":"ABM148701-2","price":98.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4517.png?v=1791104963","url":"https:\/\/www.abmium.com\/products\/tribio-salubrinal-eif2-phosphatase-inhibitor-er-stress-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}