{"product_id":"tribio-ruxolitinib-jak-inhibitor","title":"Ruxolitinib, JAK inhibitor","description":"\u003cp\u003ePotent and selective JAK1\u0026amp;2 inhibitor, IC50s=2.7, 4.5 and 322 nM forJAK1, JAK2 and JAK3 respectively. Blocks IL-6 signaling (IC50=281 nM) and proliferation of JAK2V617F+ Ba\/F3 cells (IC50=127 nM). Inhibits the proinflammatory secretome of senescent cells. The JAK1 S646P mutant is highly sensitive to ruxolitinib. Clinically useful cancer chemotherapeutic\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411064267092,"sku":"ABM148687-1","price":294.0,"currency_code":"USD","in_stock":true},{"title":"5 MG","offer_id":57411064299860,"sku":"ABM148687-2","price":137.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4511.png?v=1791104990","url":"https:\/\/www.abmium.com\/products\/tribio-ruxolitinib-jak-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}