{"product_id":"tribio-ru-521-cgas-inhibitor","title":"RU.521, cGAS inhibitor","description":"\u003cp\u003eInhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA. IC50 = 0.70 µM in dsDNA-stimulated RAW macrophages and ~0.80 µM in wild type human THP-1 cells. It is selective for cGAS with no targeting of IFNB1 protein, interferon receptors, or downstream signaling components of the JAK\/STAT pathway. RU.521 was able to significantly increase cardiac output in a mouse model of sepsis. Active in both mouse and human cell lines\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411063415124,"sku":"ABM148684-1","price":590.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411063447892,"sku":"ABM148684-2","price":173.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4140.png?v=1791104987","url":"https:\/\/www.abmium.com\/products\/tribio-ru-521-cgas-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}