{"product_id":"tribio-rk-682-tyrosine-phosphatase-inhibitor","title":"RK-682 (+\/-), Tyrosine phosphatase inhibitor","description":"\u003cp\u003eRK-682 is a protein tyrosine phosphatase inhibitor (IC50’s = 54 µM for CD45, 2.0 µM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682. Inhibits cell cycle at G1\/S. RK-682 has also been shown to inhibit PLA2 (IC50 = 16 µM), HIV-1 protease (IC50 = 84 µM), and heparanase (IC50 = 17 µM). Natural RK-682 (R-isomer) and synthetic racemic material have identical phosphatase activity. Care should be taken when using RK-682 in the presence of metal salts – RK-682 readily forms metal complexes that affects its phosphatase inhibitory activity. RK-682 has been identified as a potential promiscuous inhibitor\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"1 MG","offer_id":57411057582420,"sku":"ABM148664-1","price":482.0,"currency_code":"GBP","in_stock":true},{"title":"200 µg","offer_id":57411057615188,"sku":"ABM148664-2","price":123.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4300.png?v=1791104972","url":"https:\/\/www.abmium.com\/products\/tribio-rk-682-tyrosine-phosphatase-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}