{"product_id":"tribio-rk-33-ddx3-inhibitor","title":"RK-33, DDX3 inhibitor","description":"\u003cp\u003eInhibitor of the RNA helicase DDX3 with IC50 = 4.4-8.4 µM in high DDX3-expressing lung cancer cell lines A549, H1299, H23, and H460. Inhibition of DDX3 led to activation of cell death pathways, inhibition of Wnt pathway signaling, and abrogation of non-homologous end-joining (NHEJ) DNA repair. RK-33 was also active in colorectal cancer, prostate cancer, and medulloblastoma cancer cell lines. RK-33 caused radiosensitization in breast cancer through inhibition of mitochondrial translation. RK-33 facilitates differentiation in human embryonic stem cells (hESC) and decreases pluripotency markers as well as reducing teratoma formation\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411057320276,"sku":"ABM148663-1","price":286.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411057353044,"sku":"ABM148663-2","price":82.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4839.png?v=1791104972","url":"https:\/\/www.abmium.com\/products\/tribio-rk-33-ddx3-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}