{"product_id":"tribio-reparixin-cxcr1-2-allosteric-antagonist","title":"Reparixin, CXCR1\/2 allosteric antagonist","description":"\u003cp\u003eReparixin is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors (IC50 = 1 and 100 nM, respectively). It blocks a number of activities related to IL-8 signaling, including leukocyte recruitment (IC50 = 1 nM) without affecting receptor activation induced by other CXCR1 and CXCR2 agonists. In spontaneously hypertensive rats, 5 mg\/kg reparixin administered daily for three weeks was shown to reduce blood pressure by inhibiting hypertension-related mediators. It attenuates inflammatory responses and promotes recovery of function after traumatic lesion to the spinal cord. Reparixin blockade (100 nM) of CXCR1 has also been used to deplete a cancer stem cell population in human breast cancer cell lines in vitro\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411065413972,"sku":"ABM148643-1","price":340.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411065446740,"sku":"ABM148643-2","price":85.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2527.png?v=1791104992","url":"https:\/\/www.abmium.com\/products\/tribio-reparixin-cxcr1-2-allosteric-antagonist","provider":"ABMIUM","version":"1.0","type":"link"}