{"product_id":"tribio-pyrilamine-maleate-mepyramine-histamine-receptor-h1-inverse-agonist-sequesters-g-q-11","title":"Pyrilamine maleate (Mepyramine), Histamine receptor H1 inverse agonist; Sequesters G(q\/11)","description":"\u003cp\u003eHistamine receptor H1 inverse agonist; Sequesters G(q\/11)\u003c\/p\u003e\n\u003cp\u003eReported to be an inhibitor of calcineurin (PP2B), IC50~100 pM but this activity has been disputed. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays neurotrophic effects. Produces antidepressant-like effects in mice. Blocks the spontaneous down-regulation of Nav1.8 sodium channels expressed in Xenopus oocytes\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411059908948,"sku":"ABM148624-1","price":360.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411059941716,"sku":"ABM148624-2","price":90.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI3108.png?v=1791104978","url":"https:\/\/www.abmium.com\/products\/tribio-pyrilamine-maleate-mepyramine-histamine-receptor-h1-inverse-agonist-sequesters-g-q-11","provider":"ABMIUM","version":"1.0","type":"link"}