{"product_id":"tribio-purvalanol-a-cdk-inhibitor","title":"Purvalanol A, CDK inhibitor","description":"\u003cp\u003eCyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2\/cyclin B, cdk2\/cyclin A, cdk2\/cyclin E, cdk5\/p35 and cdk4\/cyclin D1 and respectively. Reversibly arrests synchronized cells in G1 and G2 phase. Induces ER stress-mediated apoptosis and autophagy in colon cancer cells. Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis. Cell permeable\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411058270548,"sku":"ABM148618-1","price":327.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411058303316,"sku":"ABM148618-2","price":82.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2868.png?v=1791104974","url":"https:\/\/www.abmium.com\/products\/tribio-purvalanol-a-cdk-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}