{"product_id":"tribio-nu7441-dna-pk-inhibitor","title":"NU7441, DNA-PK inhibitor","description":"\u003cp\u003eCompetitively inhibits DNA-dependent protein kinase (DNA-PK) (IC50 = 13 nM) over related kinases (IC50s 1.7 – 100 µM for mTOR, PI3K, ATM, and ATR). Sensitizes human colon cancer cells to etoposide and ionizing radiation through inhibition of double strand break repair of DNA. Enhances ionizing radiation-induced G2\/M arrest of SUNE-1 cancer cells. Reverses acquired resistance to EGFR TK inhibitor osimertinib in a NSCLC line. Causes immunosuppression via reduction in cytokines and NFκB activity\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410939224404,"sku":"ABM147463-1","price":286.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410939257172,"sku":"ABM147463-2","price":82.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4810.png?v=1791103995","url":"https:\/\/www.abmium.com\/products\/tribio-nu7441-dna-pk-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}