{"product_id":"tribio-jq1-bromodomain-inhibitor","title":"JQ1 (+\/-), Bromodomain inhibitor","description":"\u003cp\u003eJQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410912911700,"sku":"ABM147218-1","price":425.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410912944468,"sku":"ABM147218-2","price":106.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1361.png?v=1791103623","url":"https:\/\/www.abmium.com\/products\/tribio-jq1-bromodomain-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}