{"product_id":"tribio-ibrutinib-btk-inhibitor","title":"Ibrutinib, BTK inhibitor","description":"\u003cp\u003eIbrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR). Ibrutinib also potently inhibits several other kinases including BLK, BMS, FGR, EGFR, and ITK. It is a clinically useful drug to treat B cell cancers. It inhibits CLL cell migration and survival and downregulates expression of CD20. It enhanced antitumor immune responses in combination with anti PD-L1 blockade via its inhibition of ITK (IL2-inducible T-cell kinase)\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"10 MG","offer_id":57410909307220,"sku":"ABM147156-1","price":65.0,"currency_code":"GBP","in_stock":true},{"title":"50 MG","offer_id":57410909339988,"sku":"ABM147156-2","price":204.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4757.png?v=1791103615","url":"https:\/\/www.abmium.com\/products\/tribio-ibrutinib-btk-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}