{"product_id":"tribio-iacs-010759-mitochondrial-complex-i-inhibitor","title":"IACS-010759, Mitochondrial Complex I Inhibitor","description":"\u003cp\u003ePotent (IC 50 = 1.1 nM isolated mouse complex I) and selective inhibitor of complex I of the mitochondrial electron transport chain (OXPHOS). IACS-010759 displayed in vivo efficacy in glycolysis-deficient glioblastoma and AML models without cytotoxicity to normal cells. The lack of cytotoxicity to normal cells, as opposed to other complex I inhibitors, is attributed to its unique binding location on complex I. Complex I inhibition by IACS-010759 causes an ROS-induced decrease in the endogenous PP2A inhibitor CIP2A leading to cell death. It has also displayed potential in various chemotherapy-resistant cancer cell lines\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410907636052,"sku":"ABM147151-1","price":409.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410907668820,"sku":"ABM147151-2","price":144.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4475.png?v=1791103612","url":"https:\/\/www.abmium.com\/products\/tribio-iacs-010759-mitochondrial-complex-i-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}