{"product_id":"tribio-gsk872-necroptosis-inhibitor-rip3-inhibitor","title":"GSK872, Necroptosis inhibitor \/ RIP3 inhibitor","description":"\u003cp\u003ePotent and highly selective inhibitor of receptor interacting protein 3 (RIP3) (IC50 = 1.3 nM)1. Blocks necroptosis, as well as necrosis induced by virus or TLR3. At higher concentrations (~ 3 µM), GSK872 induces Caspase-8-mediated apoptosis independent of RIP3 inhibition. Reduces HIF-1α and NLRP3 inflammasome, and ameliorates brain injury and inflammation in mouse models of ischemic brain injury and acute respiratory distress\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410911109460,"sku":"ABM147110-1","price":450.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410911142228,"sku":"ABM147110-2","price":114.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4861.png?v=1791103619","url":"https:\/\/www.abmium.com\/products\/tribio-gsk872-necroptosis-inhibitor-rip3-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}