{"product_id":"tribio-bi-2536-dual-plk-brd4-inhibitor-destabilizes-myc","title":"BI-2536, Dual Plk\/BRD4 inhibitor; Destabilizes Myc","description":"\u003cp\u003eBI 2536 was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) and selective Polo-like kinase inhibitor (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) that caused mitotic arrest and apoptosis induction in various human cancer cell lines. It was later found to be a potent inhibitor (IC50 = 100nM) of BET family member BRD4 and able to potently suppress c-Myc expression in MM.1S multiple myeloma cells. BI 2536 destabilizes N-Myc by inhibiting the deactivation of the ubiquitin E3 ligase Fbw7 by Plk1\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410858516820,"sku":"ABM146704-1","price":450.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410858549588,"sku":"ABM146704-2","price":123.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4121.png?v=1791103217","url":"https:\/\/www.abmium.com\/products\/tribio-bi-2536-dual-plk-brd4-inhibitor-destabilizes-myc","provider":"ABMIUM","version":"1.0","type":"link"}