{"product_id":"tribio-bg45-hdac3-selective-inhibitor","title":"BG45, HDAC3 selective inhibitor","description":"\u003cp\u003eA potent and selective HDAC3 inhibitor (IC50 = 289 nM), IC50s for HDAC1, 2 and 6 = 2, 2.2 and \u0026gt;20 µM respectively. Inhibits tumor growth in a mouse xenograft model of human multiple myeloma. Downregulates expression of DNA methyltransferase 1. Increases expression of synaptic proteins in exogenous Aβ-treated cells and mice. Rescues synaptic damage and neuron loss in APP-transfected cells (15 µM) and APP\/PS1 mice (30 mg\/kg)\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410857173332,"sku":"ABM146702-1","price":392.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410857206100,"sku":"ABM146702-2","price":98.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI5638.png?v=1791103215","url":"https:\/\/www.abmium.com\/products\/tribio-bg45-hdac3-selective-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}