{"product_id":"tribio-belumosudil-rock2-inhibitor","title":"Belumosudil, ROCK2 inhibitor","description":"\u003cp\u003eBelumosudil is a selective inhibitor of Rho kinase 2 (ROCK2) – IC50’s: ROCK2 = 105 nM, ROCK1 = 24 µM in enzyme assays. It downregulated the ability of T cells to secrete IL-21 and IL-17, but not IFN-γ, in response to T cell stimulation in vitro via a STAT3-dependent mechanism. Belumosudil ameliorated graft-versus-host disease in multiple models and was recently approved by the FDA for the treatment of GVHD (July 2021). It has also been shown to suppress adipogenesis. Suppression of adipocyte differentiation is mediated via casein kinase 2 inhibition (IC50 = 50 nM) and not ROCK2 inhibition\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410851176788,"sku":"ABM146690-1","price":237.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410851209556,"sku":"ABM146690-2","price":74.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4165.png?v=1791103203","url":"https:\/\/www.abmium.com\/products\/tribio-belumosudil-rock2-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}