{"product_id":"tribio-as-1949490-ship2-inhibitor","title":"AS-1949490, SHIP2 inhibitor","description":"\u003cp\u003eA potent and selective inhibitor of the intracellular phosphatase SHIP2 (SH2 domain-containing inositol 5′-phosphatase 2), IC50 = 0.62 µM. Displays ca. 30-fold selectivity for SHIP2 over SHIP. Activates insulin signaling via the Akt pathway in liver and lowers glucose levels in diabetic mice. Enhances BDNF expression in cultured cortical neurons. Ameliorates ROS generation but aggravates apoptosis in CD2AP-deficient mouse podocytes\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410869199188,"sku":"ABM146637-1","price":405.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410869231956,"sku":"ABM146637-2","price":102.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI5103.png?v=1791103241","url":"https:\/\/www.abmium.com\/products\/tribio-as-1949490-ship2-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}