{"product_id":"tribio-ar7-activates-chaperone-mediated-autophagy","title":"AR7, Activates chaperone mediated autophagy","description":"\u003cp\u003eAtypical retinoid that acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway. Downstream signaling results in an increase of LAMP-2A expression. Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model. AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease-modifying strategy in Parkinson’s disease. A targetome analysis of AR7-induced CMA in cancer cells has been performed\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410867003732,"sku":"ABM146629-1","price":458.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410867036500,"sku":"ABM146629-2","price":114.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI5515-1.png?v=1791103235","url":"https:\/\/www.abmium.com\/products\/tribio-ar7-activates-chaperone-mediated-autophagy","provider":"ABMIUM","version":"1.0","type":"link"}