{"product_id":"tribio-alisertib-mln8237-aurora-a-inhibitor","title":"Alisertib (MLN8237), Aurora A inhibitor","description":"\u003cp\u003eHighly potent, ATP-competitive inhibitor selective for Aurora A kinase (Ki = 0.3 nM; IC50 = 6.7 nM) over Aurora B (IC50 = 1.5 µM); does not inhibit a large panel of other kinases. Also exhibits off-target binding of GABAA (IC50 = 0.49 µM), but no effects attributable to this binding were observed in rats. Disrupts the Aurora A \/ Myc complex, resulting in Myc degradation in Myc-amplified neuroblastomas. Inhibits tumor cell growth in vitro and in vivo, causing apoptosis and autophagy, disrupted mitosis, and increased chromosome alignment abnormalities\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410851242324,"sku":"ABM146590-1","price":376.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410851275092,"sku":"ABM146590-2","price":98.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4124.png?v=1791103203","url":"https:\/\/www.abmium.com\/products\/tribio-alisertib-mln8237-aurora-a-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}