{"product_id":"reed-biotech-sik1-polyclonal-antibody-ra29829","title":"SIK1 Polyclonal Antibody","description":"\u003cp\u003ecatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Transient role during the earliest stages of myocardial cell differentiation and\/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and\/or differentiation. Potential role in G2\/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser\/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.,subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182.,\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250135343444,"sku":"ABM5034223-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250135376212,"sku":"ABM5034223-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_29a5f835-a023-4709-bed6-d4e44515f72f.webp?v=1790235182","url":"https:\/\/www.abmium.com\/products\/reed-biotech-sik1-polyclonal-antibody-ra29829","provider":"ABMIUM","version":"1.0","type":"link"}