{"product_id":"reed-biotech-sema4a-polyclonal-antibody-ra29718","title":"SEMA4A Polyclonal Antibody","description":"\u003cp\u003esemaphorin 4A(SEMA4A) Homo sapiens This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identif\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57251322659156,"sku":"ABM5034112-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57251322691924,"sku":"ABM5034112-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_4a66705d-65e1-487a-8cc3-ab35481c17d6.webp?v=1790235156","url":"https:\/\/www.abmium.com\/products\/reed-biotech-sema4a-polyclonal-antibody-ra29718","provider":"ABMIUM","version":"1.0","type":"link"}